Dose Conversion Between Animals and Humans : A Practical Solution
2022. 10. 13. 10:34
반응형
DOI: 10.5530/ijper.56.3.108
Dose Conversion Between Animals and Humans: A Practical Solution(2022)
@Conversion by step
1. NOAEL determination
2. Scale NOAEL to HED
3. Select the more seneitive animal species
4. Divide by safety factor
5. PAD
@HED calcualtion based on BSA
@Dose conversion btw mg/kg to mg/m2
@Calculation of Km factor, Km Ratio, HED
반응형
'의약품과 질병정보 > 생물학, 신약개발, 타겟스터디' 카테고리의 다른 글
| Unlocking the promise of mRNA therapeutics (2022, nature biotechnology) (0) | 2022.12.26 |
|---|---|
| The landscape of mRNA nanomedicine (0) | 2022.12.26 |
| Relationship Between Pharmacokinetics and Pharmacogenomics and Its Impact on Drug Choice and Dose Regimens (0) | 2022.08.08 |
| 신약 개발 포인트 정리 (목표설정, TPP, Assay, 최적화, 전임상 까지) (0) | 2022.03.13 |
| 신약개발 과정 (0) | 2022.03.13 |
