Unlocking the promise of mRNA therapeutics (2022, nature biotechnology)

Reference : Rohner, E., Yang, R., Foo, K.S. et al. Unlocking the promise of mRNA therapeutics. Nat Biotechnol 40, 1586–1600 (2022). https://doi.org/10.1038/s41587-022-01491-z

 

@Enhancing protein yield

-mRNA cargo

-RNA purification

 

@Modifactions of mRNA to increase protein expression efficiency

@Packaging systems

-Lipid-based packaging

-Cell-based packaging

-Extracellular vesicle-based packaging

-Biomimetic packaging

 

@Tissue targeting

-Injection, inhalation and intranasal administration

-Catheter delivery

-Engineering packaging systems to control tropism

 

@Summary of different classes of potential mRNA therapeutics

 

@Chronic dosing

 

@Clinical studies

-VEGF mRNA and heart failure

-mRNA-encodes CRISPR therapeutic for AATR