Relationship Between Pharmacokinetics and Pharmacogenomics and Its Impact on Drug Choice and Dose Regimens

Reference : Relationship Between Pharmacokinetics and Pharmacogenomics and Its Impact on Drug Choice and Dose Regimens: Dosage, Design, and Pharmacotherapy Success
December 2018
DOI:10.1007/978-3-319-99593-9_8
In book: ADME Processes in Pharmaceutical Sciences (pp.169-202)

 

https://www.researchgate.net/publication/329332845_Relationship_Between_Pharmacokinetics_and_Pharmacogenomics_and_Its_Impact_on_Drug_Choice_and_Dose_Regimens_Dosage_Design_and_Pharmacotherapy_Success

 

@Pharmacokinetics surves of several routes of administration

 

@The drug phases in the body

 

@Efficacy and Safety of Drugs

 

@Drug variablity, Pharmacogenetics, Pharmacogenomics, and the Role of Epigenetics

 

@Type of muation in coding region

 

@Basic structure of a gene

 

@Gene vriants in drug-metabolizing enzymes

 

@Drug-metabolizing enzymes

-Phase 1 enzymes : CYP450

-Phase 2 enzymes : GST, UGT, SULTs, NATs, TPMT

 

@Drug transports

-ABC(ATP-binding cassette)

-SLC(solute linking carriers)

 

@Other polymorphic tragets

-VKORC1(vitamin K epotixe reductase complex subunit 1) - warfarin target

 

@Plasema concentration versus time curve in patients with different genotypes of P-gp, affecting absorption of drugs

 

@Absorption

 

@Distribution

 

@Drug metabolism

 

@Renal excretion

 

@Drug toxicity

 

@Dosing modifications and drug selection