The landscape of mRNA nanomedicine

Refernce : Huang, X., Kong, N., Zhang, X. et al. The landscape of mRNA nanomedicine. Nat Med 28, 2273–2287 (2022). https://doi.org/10.1038/s41591-022-02061-1

 

@Challenges regarding the clinical use of mRNA

 

@Design of mRNAs and their delivery vehicles

@Messenger RNA delivery vehicles

-Lipid-based nanoparticles

-Lipid-polymer hybrid nanoparticles

-Polymer-based nanoparticles

 

@Promising recent innovations

Innovations in mRNA engineering

-Self-amlifying mRNA

-Circular RNA

 

Innovations in mRNA delivery

-Novel mRNA delivery systems

-Biological membrane-based vehicles for mRNA delivery

-Organ- or cell-specific mRNA delivery

-Inhalable, intranasal or oral mRNA delivery

 

*경구제로 개발가능성?!*

Although oral delivery is a more challenging route for fragile mRNAs, its feasibility has been demonstrated in rodents and pigs using ingestible milli-injector capsules, holding great promise for the development of oral mRNA vaccines. BioNTech and Matinas BioPharma recently announced an exclusive research collaboration to develop potential oral mRNA vaccines using a novel lipid nano-crystal platform. This lipid nano-crystal—a stable crystalline nanoparticle containing multiple layers—is formed via the interaction of calcium and anionic phospholipids, during which active drug molecules inducing mRNAs can be loaded within the layers.

 

@Translational and clinical studies of mRNA nanomedicine

-Vaccines

-Protein therapy and gene editing

 

@Challenges of curremnt mRNA nanomdedicine

-Safety

-Adjuvanticity