Refernce : Huang, X., Kong, N., Zhang, X. et al. The landscape of mRNA nanomedicine. Nat Med 28, 2273–2287 (2022). https://doi.org/10.1038/s41591-022-02061-1
@Challenges regarding the clinical use of mRNA
@Design of mRNAs and their delivery vehicles
@Messenger RNA delivery vehicles
-Lipid-based nanoparticles
-Lipid-polymer hybrid nanoparticles
-Polymer-based nanoparticles
@Promising recent innovations
Innovations in mRNA engineering
-Self-amlifying mRNA
-Circular RNA
Innovations in mRNA delivery
-Novel mRNA delivery systems
-Biological membrane-based vehicles for mRNA delivery
-Organ- or cell-specific mRNA delivery
-Inhalable, intranasal or oral mRNA delivery
*경구제로 개발가능성?!*
Although oral delivery is a more challenging route for fragile mRNAs, its feasibility has been demonstrated in rodents and pigs using ingestible milli-injector capsules, holding great promise for the development of oral mRNA vaccines. BioNTech and Matinas BioPharma recently announced an exclusive research collaboration to develop potential oral mRNA vaccines using a novel lipid nano-crystal platform. This lipid nano-crystal—a stable crystalline nanoparticle containing multiple layers—is formed via the interaction of calcium and anionic phospholipids, during which active drug molecules inducing mRNAs can be loaded within the layers.
@Translational and clinical studies of mRNA nanomedicine
-Vaccines
-Protein therapy and gene editing
@Challenges of curremnt mRNA nanomdedicine
-Safety
-Adjuvanticity