Reference : A simple practice guide for dose conversion between animals and human
J Basic Clin Pharm. March 2016-May 2016; 7(2): 27–31. doi: 10.4103/0976-0105.177703
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/
A simple practice guide for dose conversion between animals and human
Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of ...
www.ncbi.nlm.nih.gov
@Five steps to estimate starting dose in human studies
@Dose Calcuations
-HED(mg/kg) = Animal NOAEL(mg/kg)* (Weight_animal(kg)/Weight_human(kg))^(1-0.67)
-HED(mg/kg) = Animal dose(mg/kg) * (Animal Km/Human Km)
@Human equivalent dose calculation based on body surface area
@Guidelines for maximum injection volume, by species, site location, and gauge size
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