Field Notes/Core Notes : ์‹ ์•ฝ๊ฐœ๋ฐœ
DNA ์†์ƒ ๋ณต๊ตฌ๊ธฐ์ „๊ณผ TLS, ํ•ญ์•”์ œ ๋‚ด์„ฑ
2022.03.13
DNA damage repair BER (base excision repair) ์†์ƒ๋œ ์—ผ๊ธฐ๋ฅผ ์ž˜๋ผ๋‚ด๊ณ  ๋ณต๊ตฌ NER (nucleotide excision repair) ๋‰ดํด๋ ˆ์˜คํƒ€์ด๋“œ ๋‹จ์œ„ ๋ณต๊ตฌ MMR (mismatch mediated repair) ๋ณต์ œ ๊ณผ์ •์—์„œ์˜ ์—๋Ÿฌ ๋ณต๊ตฌ DNA double-strand break repair ์ด์ค‘๊ฐ€๋‹ฅ ์†์ƒ ๋ณต๊ตฌ a. NHEJ (non-homologous end joining) ์†์ƒ ๋ถ€์œ„๋ฅผ ์—ฐ๊ฒฐํ•˜๋‹ค๋ณด๋‹ˆ INDEL(insertion & deletion) ๋ฐœ์ƒ b. HDR (homology directed repair) ์ธ์ ‘ํ•œ ์ƒ๋™์—ผ์ƒ‰์ฒด์˜ ๋™์ผ ๋ถ€๋ถ„ ์œ ์ „์ •๋ณด๋ฅผ ํ™œ์šฉํ•˜์—ฌ ๋ณต๊ตฌ TLS (translesion synthesis) DNA ์†์ƒ์— ๋Œ€ํ•œ tolerance pathwa..