Reference : A simple practice guide for dose conversion between animals and human J Basic Clin Pharm. March 2016-May 2016; 7(2): 27–31. doi: 10.4103/0976-0105.177703 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/ A simple practice guide for dose conversion between animals and human Understanding the concept of extrapolation of dose between species is important for pharmaceutical researche..

DOI: 10.5530/ijper.56.3.108 Dose Conversion Between Animals and Humans: A Practical Solution(2022) @Conversion by step 1. NOAEL determination 2. Scale NOAEL to HED 3. Select the more seneitive animal species 4. Divide by safety factor 5. PAD @HED calcualtion based on BSA @Dose conversion btw mg/kg to mg/m2 @Calculation of Km factor, Km Ratio, HED