Reference: E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration (Front. Mol. Neurosci., 2017) https://doi.org/10.3389/fnmol.2017.00151 E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to neurodegene..