Field Notes/Core Notes : ์‹ ์•ฝ๊ฐœ๋ฐœ
NLRP3์™€ Inflammasome, PRR
2022.12.26
Immune system -๋‚ด์žฌ์  ๋ฉด์—ญ๊ธฐ๋Šฅ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์€ ํŒจํ„ด์„ PRR์— ์˜ํ•ด ์ธ์‹ํ•˜๋ฉฐ ์ด๋ค„์ง. (1)PAMPs(pathogen associated molecular patterns) ์นจ์ž…ํ•œ ๋ณ‘์›๊ท ์—์„œ ์œ ๋ž˜๋˜๋Š” ๋ณ‘์›์ฒด ๊ด€๋ จ ๋ถ„์ž ํŒจํ„ด (2)DAMPs(danger associated molecular patterns) ๋‚ด์žฌ์  ์ŠคํŠธ๋ ˆ์Šค ์œ ๋ฐœ ์œ„ํ—˜ ๊ด€๋ จ ๋ถ„์ž ํŒจํ„ด, ์™ธ๋ถ€ ๋ณ‘์›๊ท  ์—†์ด๋„ ๋ฐœ์ƒํ•˜๋Š” ๋ฌด๊ท ์„ฑ ์—ผ์ฆ -PRR(germline encoded pattern-recognition receptors, ๋ฐฐ์„  ์œ ์ „ ๋ถ€ํ˜ธํ™” ํ˜•ํƒœ ์ธ์‹ ์ˆ˜์šฉ์ฒด): PRR์€ ์ธํ”Œ๋ผ๋งˆ์ข€ ๋ณตํ•ฉ์ฒด๋ฅผ ๊ตฌ์„ฑํ•˜๋Š” ์ค‘์š”ํ•œ ์š”์†Œ๋กœ PAMPs, DAMPs์— ์˜ํ•ด ํ™œ์„ฑํ™” --> caspase-1์ด ํ™œ์„ฑํ™”๋˜๋ฉด์„œ IL-1 ๊ณ„์—ด ์—ผ์ฆ์„ฑ ์‚ฌ์ดํ† ์นด์ธ๋“ค์„ ํ™œ์„ฑ ํ˜•ํƒœ..
Field Notes/Core Notes : ์‹ ์•ฝ๊ฐœ๋ฐœ
Inflammasome๊ณผ NLRP3
2022.03.13
๋ฉด์—ญ ๋‚ด์žฌ์  ๋ฉด์—ญ๊ธฐ๋Šฅ์€ ๋‹ค์Œ๊ณผ ๊ฐ™์€ ํŒจํ„ด์„ PRR์— ์˜ํ•ด ์ธ์‹ํ•˜๋ฉฐ ์ด๋ค„์ง. (1)PAMPs(pathogen associated molecular patterns) : ์นจ์ž…ํ•œ ๋ณ‘์›๊ท ์—์„œ ์œ ๋ž˜๋˜๋Š” ๋ณ‘์›์ฒด ๊ด€๋ จ ๋ถ„์ž ํŒจํ„ด (2)DAMPs(danger associated molecular patterns) : ๋‚ด์žฌ์  ์ŠคํŠธ๋ ˆ์Šค ์œ ๋ฐœ ์œ„ํ—˜ ๊ด€๋ จ ๋ถ„์ž ํŒจํ„ด, ์™ธ๋ถ€ ๋ณ‘์›๊ท  ์—†์ด๋„ ๋ฐœ์ƒํ•˜๋Š” ๋ฌด๊ท ์„ฑ ์—ผ์ฆ PRR(germline encoded pattern-recognition receptors, ๋ฐฐ์„  ์œ ์ „ ๋ถ€ํ˜ธํ™” ํ˜•ํƒœ ์ธ์‹ ์ˆ˜์šฉ์ฒด) PRR์€ ์ธํ”Œ๋ผ๋งˆ์ข€ ๋ณตํ•ฉ์ฒด๋ฅผ ๊ตฌ์„ฑํ•˜๋Š” ์ค‘์š”ํ•œ ์š”์†Œ๋กœ PAMPs, DAMPs์— ์˜ํ•ด ํ™œ์„ฑํ™” caspase-1์ด ํ™œ์„ฑํ™”๋˜๋ฉด์„œ IL-1 ๊ณ„์—ด ์—ผ์ฆ์„ฑ ์‚ฌ์ดํ† ์นด์ธ๋“ค์„ ํ™œ์„ฑ ํ˜•ํƒœ๋กœ ์ž๋ฆ„ ์—ผ์ฆ์„ฑ ์„ธํฌ ์‚ฌ๋ฉธ..